Leandro Martinez gave the hosts hope by combining with Cristian Colman and beating goalkeeper Cesar at his near post after some sloppy Flamengo defending.
The single-leg match was played behind closed doors in the city of Petah Tikva, after Beer Sheva's Turner Stadium was closed last month amid structural concerns.
The following fixtures are scheduled for Saturday: Borussia Monchengladbach host Union Berlin, Bayer Leverkusen face Leipzig, Mainz meet newly-promoted Stuttgart, Augsburg clash with Borussia Dortmund, newly-promoted Arminia Bielefeld take on Cologne, and Schalke face Werder Bremen. Enditem
China's national team player Gong Xiangyu notched up seven points to help Jiangsu take the first set.
Also on Thursday, Shanghai surprised Tianjin with a straight-set win (27-25, 25-23, 25-22). Enditem
A few weeks ago, Union Berlin striker Sebastian Polter was suspended following a corona-based wage dispute.
The Bavarian federal government recently changed the rules for people returning from high-risk countries. To re-enter Germany, a negative test or self-quarantine is required.
Jiangsu and Guangzhou staged a hard-fought game with constant clashes. Alex Teixeira opened the scoring for Jiangsu in the remaining minutes of the first half. After He Chao pulled one back for Guangzhou in the 71st minute, Eder Citadin Martins gave Jiangsu the lead again four minutes later.
In Tuesday's match, Guoan was up by three goals before the interval, with goals from Yu Yang, Jonathan Viera and Fernando Lucas Martins.
Widespread reports in the Israeli media suggest the 27-year-old will join Dubai's Al-Nasr SC, who play in the UAE Pro League.
Philippe Coutinho also has a lot to prove after his loan spell at Bayern, while questions remain over what style of play Koeman will look to impose.